"Too big to fail" in crypto primarily refers to systemically important assets like major stable coins and large exchanges. 

Key examples include:

Tether (#USDT ): Largest stable coin, deeply integrated with traditional finance via its vast U.S. Treasury holdings.

USD Coin (#USDC ): Another significant, regulated stable coin.

Major Exchanges: Their failures could transmit market shocks. 

A separate, volatile meme coin on #solana is literally named "Too big to fail" ( #TBTF ).